Title : Evaluation of pregnancy outcome as a consequence of intravaginal inoculation with various microorganisms in mouse model
The concept of infertility as a result of asymptomatic microbial colonization of the female reproductive tract has been neglected to date. However, increasing incidence of infertility and advanced research has drawn attention towards this idea. Many of these micro-organisms have been reported to bring about adverse changes in sperm parameters viz. motility, viability Magnesium dependent ATPase activity and acrosome reaction in vitro, but their in vivo potential to cause infertility is still a controversy. The present study indicates that colonization of mouse vagina with microorganisms possessing sperm impairing property could result in infertility whereas non sperm impairing microorganisms failed to do so. When the intravaginal inoculation of sperm impairing microorganisms was carried out into female BALB/c mice for 10 consecutive days with mating of mice on day 12, 100% decrease in fertility was observed in all the groups as compared with control mice receiving PBS alone. Furthermore no clinical or histopathological changes could be observed viz. ovary, uterus and vagina suggesting that colonization of the genital tract with sperm impairing microorganisms is not accompanied by signs of inflammation. Thus this study tends to align with the opinion that presence of sperm impairing microorganisms in female genital tract might be altering the vaginal milieu due to release of microbial components which in turn impair sperm parameters thereby leading to infertility.
What will audience learn from your presentation?
- The audience will get deeper insights into the relationship between microorganisms and female infertility
- This research can be used further to better understand the mechanisms of infertility caused by microorganisms
- New therapeutic measures can be exploited to ameliorate the infertility caused by various microorganisms