International Conference and Expo on

Clinical Microbiology

June 17-18, 2022 | Online Event

ICCM 2022

Evaluation of pregnancy outcome as a consequence of intravaginal inoculation with various microorganisms in mouse model

Speaker at Clinical Microbiology 2022 - Vijay Prabha
Panjab University, India
Title : Evaluation of pregnancy outcome as a consequence of intravaginal inoculation with various microorganisms in mouse model


The concept of infertility as a result of asymptomatic microbial colonization of the female reproductive tract has been neglected to date. However, increasing incidence of infertility and advanced research has drawn attention towards this idea. Many of these micro-organisms have been reported to bring about adverse changes in sperm parameters viz. motility, viability Magnesium dependent ATPase activity and acrosome reaction in vitro, but their in vivo potential to cause infertility is still a controversy. The present study indicates that colonization of mouse vagina with microorganisms possessing sperm impairing property could result in infertility whereas non sperm impairing microorganisms failed to do so. When the intravaginal inoculation of sperm impairing microorganisms was carried out into female BALB/c mice for 10 consecutive days with mating of mice on day 12, 100% decrease in fertility was observed in all the groups as compared with control mice receiving PBS alone. Furthermore no clinical or histopathological changes could be observed viz. ovary, uterus and vagina suggesting that colonization of the genital tract with sperm impairing microorganisms is not accompanied by signs of inflammation. Thus this study tends to align with the opinion that presence of sperm impairing microorganisms in female genital tract might be altering the vaginal milieu due to release of microbial components which in  turn impair sperm parameters thereby leading to infertility.
What will audience learn from your presentation?

  • The audience will get deeper insights into the relationship between microorganisms and female infertility
  • This research can be used further to better understand the mechanisms of infertility caused by microorganisms
  • New therapeutic measures can be exploited to ameliorate the infertility caused by various microorganisms  


Dr. (Mrs) Vijay Prabha, is working as Professor in the Department of Microbiology, Panjab  University, Chandigarh, India. She has 30 years of teaching and 40 years of research experience.Her area of expertise is “Role of microorganisms in male and female infertility and exploitation of microbial factors as male and female contraceptive agents”. She has guided number of M.Sc. and Ph.D students.She has about 90 publications in national and international journals. She has also presented her work in various national and international conferences as an invited speaker. She is life member of Association of Microbiologists of India and Panjab University Research Journal of Science. She is editorial board member of various international and national journals.