Genomics and Genome Sequencing of Microorganisms

The requirement to grow bacteria in culture has traditionally constrained microbial research. DNA sequencing still requires huge volumes of DNA template generated from homogeneous cell cultures, even in the modern era of genomics. Microbial whole-genome sequencing is a useful technology for mapping the genomes of new organisms, completing the genomes of existing organisms, and comparing genomes from different samples. Generating accurate reference genomes, microbial identification, and other comparative genomic investigations all require sequencing whole bacterial, viral, and other microbial genomes. The great majority of microbial species are uncultivated, and until recently, almost half of all known bacterial phyla were only identifiable by their ribosomal RNA gene sequence. Genomes of uncultivated species are rapidly filling in unsequenced branches of the microbial phylogenetic tree, due to the advent of single-cell sequencing.

• Genome Evolution of Complex Traits
• Genome Sequence Quality
• Genomics and Experimental Evolution
• Genomics of Pathogen Emergence
• Metagenomics
• Microbial Comparative Genomics
• Microbial Whole-Genome Resequencing
• Microbial Whole-Genome Sequencing